منابع مشابه
PI3K-PKB/Akt pathway.
Identification of the phosphoinositide-3-kinase–protein kinase B/Akt (PI3K-PKB/Akt) pathway and activating receptor tyrosine kinases (RTKs) began in earnest in the early 1980s through vigorous attempts to characterize insulin receptor signaling (for review, see Alessi 2001; Brazil and Hemmings 2001). These humble beginnings led to the identification of the components and mechanism of insulin re...
متن کاملAKT/PKB Signaling: Navigating Downstream
The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approache...
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Wzrost i rozwój in utero jest kompleksowym i dynamicznym procesem, wymagającym interakcji między organizmem matki i płodu. Dostarczenie makro – i mikroskładników odżywczych, tlenu i sygnałów endokrynnych ma kluczowe znaczenie dla zapewnienia wysokiego poziomu proliferacji, wzrostu i różnicowania komórek, a zakłócenia w odżywianiu wpływają niekorzystnie nie tylko na wzrost płodu, ale także na zd...
متن کاملKinetic mechanism of AKT/PKB enzyme family.
AKT/PKB is a phosphoinositide-dependent serine/threonine protein kinase that plays a critical role in the signal transduction of receptors. It also serves as an oncogene in the tumorigenesis of cancer cells when aberrantly activated by genetic lesions of the PTEN tumor suppressor, phosphatidylinositol 3-kinase, and receptor tyrosine kinase overexpression. Here we have characterized and compared...
متن کاملAKT/PKB Signaling: Navigating the Network.
The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25 years ago and has been the focus of tens of thousands of studies in diverse fields of biology and medicine. There have been many advances in our knowledge of the upstream regulatory inputs into AKT, key multifunctional downstream signaling nodes (GSK3, FoxO, mTORC1), which greatly expand the functional repertoir...
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ژورنال
عنوان ژورنال: Space – Society – Economy
سال: 2013
ISSN: 2451-3547,1733-3180
DOI: 10.18778/1733-3180.12.09